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Published TCIMAIL newest issue No.197
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CAS RN: 119478-56-7 | Product Number: M2279
Meropenem Trihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
82,00 €
|
6 | ≥80 |
|
| 5G |
287,00 €
|
2 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2279 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__5N__3O__5S·3H__2O = 437.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 119478-56-7 |
| Related CAS RN | 96036-03-2 |
| PubChem Substance ID | 135727273 |
| Merck Index (14) | 5900 |
| MDL Number | MFCD08600005 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | -17.0 to -21.0 deg(C=0.44, H2O) |
| Water | 11.4 to 13.4 % |
Properties (reference)
| Specific Rotation | -18° (C=0.44,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| RTECS# | CL5446507 |
Transport Information:
| HS Number | 2941900000 |
Application
Meropenem: A Carbapenem Antibiotic with Broad Spectrum of Activity and Stability to β-Lactamases
Meropenem, which is the second carbapenem antibiotic, has a broad spectrum of activity that includes activity against gram-positive bacteria and excellent gram-negative aerobic and anaerobic activity. It has enhanced gram-negative activity relative to imipenem (the first carbapenem antibiotic)-cilastatin and often retains activity against strains resistant to third-generation cephalosporins and imipenem-cilastatin. It has increased stability to β-lactamases compared with imipenem.
References
- Novel carbapenem-hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
- Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems
- T. Köhler, M. Michea-Hamzehpour, S. F. Epp, J.-C. Pechere, Antimicrob. Agents Chemother. 1999, 43, 424.
- Meropenem: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy
- Comparative review of the carbapenems
- Meropenem: a review of its use in the treatment of serious bacterial infections
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