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Published TCIMAIL newest issue No.198
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CAS RN: 7179-49-9 | Product Number: L0166
Lincomycin Hydrochloride Monohydrate
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Purity: >98.0%(T)(qNMR)
Synonyms:
- Lincocin Hydrochloride Monohydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€114.00
|
1 | Contact Us |
|
| 25G |
€379.00
|
1 | 23 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0166 |
| Purity / Analysis Method | >98.0%(T)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__8H__3__4N__2O__6S·HCl·H__2O = 461.02 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 7179-49-9 |
| Related CAS RN | 859-18-7&154-21-2 |
| Reaxys Registry Number | 3580436 |
| PubChem Substance ID | 87572117 |
| Merck Index (14) | 5500 |
| MDL Number | MFCD00167245 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 151.0 to 157.0 °C |
| Specific rotation [a]20/D | +134 to +139 deg(C=1, H2O) |
| Solubility in Water | almost transparency |
| Water | 3.7 to 4.5 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 154 °C |
| Specific Rotation | 137° (C=1,H2O) |
GHS
Related Laws:
| RTECS# | RH6315500 |
Transport Information:
| HS Number | 2941100000 |
Application
Lincomycin Hydrochloride: A Lincosamide Antibiotic with Activity against Anaerobic Bacteria
Lincomycin hydrochloride is a lincosamide antibiotic isolated from the actinomyces Streptomyces lincolnensis. A congener compound, clindamycin [C2256], is derived from lincomycin to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Lincomycin has broad activity against anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria with a few exceptions, but less activity against most aerobic Gram-negative bacteria. Lincomycin interacts with the 50s subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Bacterial resistance to clindamycin and lincomycin may be caused by methylation of bacterial 23S ribosomal RNA.
References
- Lincomycin related antibiotics (a review)
- Comparative metabolism of lincomycin in the swine, chicken, and rat (a review)
- Lincomycin, clindamycin and their applications (a review)
PubMed Literature
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