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CAS RN: 58-93-5 | Product Number: H1274
Hydrochlorothiazide
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Purity: >97.0%(HPLC)(N)
Synonyms:
- 7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide
- 6-Chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
- 6-Chloro-7-sulfamoyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
25,00 €
|
7 | 16 |
|
| 25G |
78,00 €
|
3 | 36 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | H1274 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__7H__8ClN__3O__4S__2 = 297.73 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58-93-5 |
| Reaxys Registry Number | 625101 |
| PubChem Substance ID | 87560983 |
| Merck Index (14) | 4781 |
| MDL Number | MFCD00051765 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 269 °C |
| Maximum Absorption Wavelength | 318(H2O) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 722 mg/l 25 °C |
| Solubility (soluble in) | Methanol, Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 200-403-3 |
| RTECS# | DK9100000 |
Transport Information:
| HS Number | 2935909099 |
Application
Hydrochlorothiazide: A Thiazide Diuretic
Hydrochlorothiazide, a thiazide diuretic, affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately molecular equivalent amounts. Although the mechanism of the antihypertensive effect remains unknown exactly, thiazide diuretics are often used with AT1 receptor antagonists, especially valsartan [V0112], in clinical use. (The product is for research purpose only.)
References
- Sodium chloride absorption by the urinary bladder of the winter flounder. A thiazide-sensitive, electrically neutral transport system
- Valsartan/hydrochlorothiazide. A review of its pharmacology, therapeutic efficacy and place in the management of hypertension
- Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics (a review)
- Analytical profiles of drug substances. Hydrochlorothiazide (a review on the detection, preparation, and metabolism)
- Simultaneous determination of valsartan and hydrochlorothiazide in tablets by first-derivative ultraviolet spectrophotometry and LC
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