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Published TCIMAIL newest issue No.197
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CAS RN: 75607-67-9 | Product Number: F0913
Fludarabine Monophosphate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate
- 9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate
- 2-F-ara-AMP
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
30,00 €
|
1 | 7 |
|
| 100MG |
98,00 €
|
1 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0913 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3FN__5O__7P = 365.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 75607-67-9 |
| Reaxys Registry Number | 8167686 |
| PubChem Substance ID | 253660324 |
| Merck Index (14) | 4126 |
| MDL Number | MFCD00866418 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +11.0 to +13.0 deg(C=0.5, H2O) |
Properties (reference)
| Melting Point | 203 °C(dec.) |
| Specific Rotation | 12° (C=0.5,H2O) |
| Degree of solubility in water | 8.9 g/l 20 °C |
| Solubility (insoluble in) | Ethanol, Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. |
Related Laws:
| RTECS# | UO7440900 |
Transport Information:
| HS Number | 2934999090 |
Application
Fludarabine phosphate (2-F-ara-AMP): An Inhibitor of DNA Synthesis
Fludarabine phosphate (2-F-ara-AMP) is an adenine nucleoside analog that is converted first to 9-β-D-arabinofuranosyl-2-fluoradenine (2-F-ara-A) and then into the active metabolite 2-F-ara-A triphosphate (F-ara-ATP). The triphosphate inhibits the synthesis of primer RNA and DNA by DNA polymerase primase complex, and also induces cell death through apoptosis. Fludarabine phosphate shows activity against chronic lymphocytic leukemia (CLL) and indolent lymphoma. (The product is for research purpose only.)
References
- Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity
- Inhibition of the 3'→5' exonuclease of human DNA polymerase ε by fludarabine-terminated DNA
- The role of fludarabine-induced apoptosis and cell cycle synchronization in enhanced murine tumor radiation response in vivo
- Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia
- In vitro cytotoxic effects of fludarabine (2-F-ara-A) in combination with commonly used antileukemic agents by isobologram analysis
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