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CAS RN: 153439-40-8 | Product Number: F0698

Fexofenadine Hydrochloride


Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
1G
91,00 €
1   ≥80 
5G
313,00 €
1   26  

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Product Number F0698
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__3__2H__3__9NO__4·HCl = 538.13 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (<0°C)
Condition to Avoid Heat Sensitive
Packaging and Container 1G-Glass Bottle with Plastic Insert (View image)
CAS RN 153439-40-8
Related CAS RN 138452-21-8&83799-24-0
Reaxys Registry Number 7900041
PubChem Substance ID 87561226
Merck Index (14) 4068
MDL Number

MFCD00865710

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Solubility (soluble in) Methanol
GHS
Related Laws:
Transport Information:
HS Number 2933399990
Application
Fexofenadine: A Second-Generation Selective Histamine H1 Receptor Antagonist

Fexofenadine is a second-generation selective histamine H1 receptor antagonist that does not cross the blood brain barrier. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked. Grapefruit and other fruit juices have recently been shown to be potent inhibitors of a number of organic anion-transporting polypeptides (OATPs) in the gastrointestinal tract. Thus, these juices decrease the absorption of fexofenadine by inhibiting the activity of OATPs. For your reference, fexofenadine is the active metabolite of terfenadine [T3977]. (The product is for research purpose only.)

References


PubMed Literature


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