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Published TCIMAIL newest issue No.197
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CAS RN: 84611-23-4 | Product Number: E1026
Erdosteine
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Purity: >98.0%(GC)(T)
Synonyms:
- N-(Tetrahydro-2-oxo-3-thienyl)-3-thiapentanedioic Acid Monoamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
53,00 €
|
1 | 20 |
|
| 5G |
169,00 €
|
Contact Us | 23 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1026 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__1__1NO__4S__2 = 249.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 84611-23-4 |
| Reaxys Registry Number | 6972806 |
| PubChem Substance ID | 253661978 |
| Merck Index (14) | 3647 |
| MDL Number | MFCD00867664 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 160.0 to 164.0 °C |
Properties (reference)
| Melting Point | 162 °C |
| Maximum Absorption Wavelength | 236(H2O) nm |
GHS
Related Laws:
| RTECS# | AJ1476200 |
Transport Information:
| HS Number | 2934999090 |
Application
Erdosteine: A Unique Prodrug with a Multifactorial Mechanism of Action
Erdosteine is an inactive prodrug with a multifactorial mechanism of action, namely: mucolytic, antibacterial, antioxidant and anti-inflammatory activity. Following first-pass metabolism, the opening of the thiolactone ring and deacetylation of the aliphatic side chain, the methabolite is the active metabolite of erdosteine owing to its free thiol group. Erdosteine is currently used for treatment of chronic obstructive pulmonary disease (COPD). (The product is for research purpose only.)
References
- Erdosteine (a review)
- Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts
- Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats
- Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats
- An overview of erdosteine antioxidant activity in experimental research (a review)
- Erdosteine: antitussive and anti-inflammatory effects (a review)
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