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Published TCIMAIL newest issue No.197
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CAS RN: 33286-22-5 | Product Number: D3662
(+)-cis-Diltiazem Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€81.00
|
1 | ≥80 |
|
| 25G |
€258.00
|
1 | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D3662 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__6N__2O__4S·HCl = 450.98 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 33286-22-5 |
| Related CAS RN | 42399-41-7 |
| Reaxys Registry Number | 4228706 |
| PubChem Substance ID | 87560433 |
| MDL Number | MFCD00069252 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | 114 to 122 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 210 °C |
| Specific Rotation | 118° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 251-443-3 |
| RTECS# | DL0310000 |
Transport Information:
| HS Number | 2934999090 |
Application
Diltiazem: A Calcium Channel Antagonist
Diltiazem, a calcium channel antagonist, is a potent vasodilator and used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. Diltiazem is metabolized by and acts as an inhibitor of cytochrome P-450 3A (CYP3A). (The product is for research purpose only.)
References
- Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialyzed heart cells
- Diltiazem. A review of its pharmacological properties and therapeutic efficacy (a review)
- Diltiazem. A reappraisal of its pharmacological properties and therapeutic use (a review)
- Diltiazem hydrochloride (a review)
- Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation
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