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Published TCIMAIL newest issue No.197
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CAS RN: 52214-84-3 | Product Number: C2667
Ciprofibrate
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Purity: >98.0%(GC)(T)
Synonyms:
- 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
56,00 €
|
1 | 2 |
|
| 5G |
179,00 €
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2667 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__3H__1__4Cl__2O__3 = 289.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 52214-84-3 |
| Reaxys Registry Number | 1984981 |
| PubChem Substance ID | 160871346 |
| Merck Index (14) | 2313 |
| MDL Number | MFCD00467135 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 116.0 to 120.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 118 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
| EC Number | 257-744-6 |
| RTECS# | UF0880000 |
Transport Information:
| HS Number | 2918999090 |
Application
Clofibrate: Antilipemic with Activity against Peroxisome Proliferator-Activated Receptors (PPARs)
The fibrates, including ciprofibrate, are lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates increase the high density lipoprotein (HDL) cholesterol fraction. The precise mechanisms of action remain unknown, but it has been reported that the major modes of action of the fibrates as follows: VLDL catabolism by increased lipoprotein and hepatic triglyceride lipase activities; suppression of triglyceride biosynthesis by acetyl-CoA carboxylase enzyme inhibition and attenuation of cholesterol biosynthesis by inhibition of the rate-limiting HMG-CoA reductase.
Since the late 1990s, it has been reported that fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs) which activation increases HDL cholesterol synthesis, stimulates "reverse" cholesterol transport and reduces triglycerides. (The product is for research purpose only.)
Since the late 1990s, it has been reported that fibrates activate specific transcription factors belonging to the nuclear hormone receptor superfamily, termed peroxisome proliferator-activated receptors (PPARs) which activation increases HDL cholesterol synthesis, stimulates "reverse" cholesterol transport and reduces triglycerides. (The product is for research purpose only.)
References
- Mechanism of action of fibrates on lipid and lipoprotein metabolism (a review)
- The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
- Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-α agonist ciprofibrate
- Determination of bezafibrate, ciprofibrate and fenofibric acid in human plasma by high-performance liquid chromatography
Application
Studies on Peroxisome Proliferator-Activated Receptors (PPARs)
References
- Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
- Mechanism of action of fibrates on lipid and lipoprotein metabolism
- Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity
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