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Published TCIMAIL newest issue No.197
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CAS RN: 1428-67-7 | Product Number: B4385
Diarylpropionitrile
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Purity: >98.0%(GC)
Synonyms:
- 2,3-Bis(4-hydroxyphenyl)propionitrile
- DPN
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€51.00
|
1 | 31 |
|
| 50MG |
€199.00
|
1 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4385 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__3NO__2 = 239.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 1428-67-7 |
| Reaxys Registry Number | 3337109 |
| PubChem Substance ID | 253662391 |
| MDL Number | MFCD01695412 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 200.0 to 204.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 203 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | UG0900000 |
Transport Information:
| HS Number | 2926907090 |
Application
2,3-Bis(4-hydroxyphenyl)propionitrile: A Selective Agonist on Estrogen Receptor beta (ERβ)
2,3-Bis(4-hydroxyphenyl)propionitrile (commonly known as diarylpropionitrile) is a selective agonist on estrogen receptor beta (ERβ). It exists as a racemic mixture of two enantiomers, R-form and S-form. Evaluations of the enantiomers as an ERβ antagonist have been reported.
References
- Estrogen Receptor-β Potency-Selective Ligands: Structure-Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues
- Estrogen receptors alfa (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11
- ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats
- Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines
- Diarylpropionitrile (DPN) Enantiomers: Synthesis and Evaluation of Estrogen Receptor β-Selective Ligands
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