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CAS RN: 151060-21-8 | Product Number: B4354
Balofloxacin Dihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidyl]-4-oxoquinoline-3-carboxylic Acid Dihydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
55,00 €
|
1 | 1 |
|
| 5G |
175,00 €
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4354 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__4FN__3O__4·2H__2O = 425.46 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 151060-21-8 |
| Related CAS RN | 127294-70-6 |
| Reaxys Registry Number | 8362117 |
| PubChem Substance ID | 253661053 |
| MDL Number | MFCD00864925 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(as Dihydrate) |
| Water | 6.5 to 10.5 % |
Properties (reference)
| Melting Point | 135 °C |
GHS
Related Laws:
| RTECS# | VB1993755 |
Transport Information:
| HS Number | 2933491090 |
Application
Balofloxacin: An 8-Methoxyfluoroquinolone Antibiotic
Balofloxacin (Q-35) is a fluoroquinolone antibiotic, in which a OMe group is substituted at the 8 position of the quinoline nucleus. In vitro, it has a broad spectrum of activity against Gram-positive bacteria (eg. Mycoplasma pneumoniae and Staphylococcus aureus including MRSA) which is almost equal to that of sparfloxacin [S0896] or tosufloxacin [T2506]. In contrast, its activity against Gram-negative bacteria is lower. In animal studies, balofloxacin do not exhibit any phototoxicity which is a toxicity of fluoroquinolone antibiotic, in general.
References
- In vitro and in vivo activities of Q-35, a new fluoroquinolone, against Mycoplasma pneumoniae
- Improved bactericidal activity of Q-35 against quinolone-resistant staphylococci
- Photostability and biological activity of fluoroquinolones substituted at the 8 position after UV irradiation
- Reduced phototoxicity of a fluoroquinolone antibacterial agent with a methoxy group at the 8 position in mice irradiated with long-wavelength UV light
- Laboratory and clinical study of balofloxacin (Q-35), a new fluoroquinolone, in urinary tract infection
- Development and validation of analytical method for estimation of Balofloxacin in bulk and pharmaceutical dosage form
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