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CAS RN: 2438-72-4 | Product Number: B4179
Bufexamac
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Purity: >98.0%(HPLC)
Synonyms:
- 2-(4-Butoxyphenyl)acetohydroxamic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€55.00
|
2 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4179 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__7NO__3 = 223.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 2438-72-4 |
| Reaxys Registry Number | 2646848 |
| PubChem Substance ID | 253662254 |
| Merck Index (14) | 1474 |
| MDL Number | MFCD00078936 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 164 °C(dec.) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 219-451-1 |
| RTECS# | AK8280000 |
Transport Information:
| HS Number | 2928009090 |
Application
Bufexamac: A Non-Steroidal Anti-Inflammatory Drug (NSAID)
Bufexamac is a non-steroidal anti-inflammatory drug (NSAID). Bufexamac acts by inhibiting the enzyme cyclooxygenase (COX), which directs the synthesis of a family of cellular regulators called prostaglandins (PGS). Recently, bufexamac has been reported as an antioxidant and a class IIb (HDAC6, HDAC10) HDAC inhibitor.
References
- Bufexamac (a review)
- M. Alhadeff, Drugs Today 1976, 12, 435.
- Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action
- Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
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