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Published TCIMAIL newest issue No.197
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CAS RN: 72773-04-7 | Product Number: B3920
1H-Benzotriazole-1-carboxaldehyde
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Purity: >95.0%(GC)
Synonyms:
- 1-Formyl-1H-benzotriazole
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€88.00
|
1 | 16 |
|
| 5G |
€301.00
|
1 | 27 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B3920 |
| Purity / Analysis Method | >95.0%(GC) |
| Molecular Formula / Molecular Weight | C__7H__5N__3O = 147.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 72773-04-7 |
| Reaxys Registry Number | 510150 |
| PubChem Substance ID | 172089012 |
| MDL Number | MFCD00239420 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 94.0 to 98.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 97 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
N-Formylation Reaction
Typical Procedure:
A solution of amine 1 (1.42 g, 3.86 mmol) in THF (84 mL) is treated with 1H-benzotriazole-1-carboxaldehyde (738 mg, 5.02 mmol). The mixture is stirred for 20 h at rt then 2N NaOH aqueous solution is added. The solution is stirred for 15 min at rt then water is added and THF is removed under reduced pressure. The aqueous phase is extracted with dichloromethane, and the combined organic layer is dried over MgSO4, filtered and concentrated under reduced pressure. The residue is purified by silica gel flash chromatography (Hexane → Hexane : AcOEt = 3 : 2) to give 2 (1.02 g, Y. 67%) as a colorless oil.
A solution of amine 1 (1.42 g, 3.86 mmol) in THF (84 mL) is treated with 1H-benzotriazole-1-carboxaldehyde (738 mg, 5.02 mmol). The mixture is stirred for 20 h at rt then 2N NaOH aqueous solution is added. The solution is stirred for 15 min at rt then water is added and THF is removed under reduced pressure. The aqueous phase is extracted with dichloromethane, and the combined organic layer is dried over MgSO4, filtered and concentrated under reduced pressure. The residue is purified by silica gel flash chromatography (Hexane → Hexane : AcOEt = 3 : 2) to give 2 (1.02 g, Y. 67%) as a colorless oil.
References
- Synthesis of the tetracyclic core of daphnilactone B-type and Yuzurimine-type alkaloids
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