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Published TCIMAIL newest issue No.197
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CAS RN: 315-30-0 | Product Number: A0907
Allopurinol
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Purity: >98.0%(T)
Synonyms:
- 4-Hydroxypyrazolo[3,4-d]pyrimidine
- 1H-Pyrazolo[3,4-d]pyrimidin-4-ol
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
26,00 €
|
2 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0907 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__4N__4O = 136.11 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 315-30-0 |
| Reaxys Registry Number | 608611 |
| PubChem Substance ID | 87562416 |
| SDBS (AIST Spectral DB) | 4122 |
| Merck Index (14) | 279 |
| MDL Number | MFCD00599413 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Solubility in 1mol/L NaOH | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 384 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.48 g/l 25 °C |
| Solubility (insoluble in) | Chloroform, Ethanol, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 206-250-9 |
| RTECS# | UR0785000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Allopurinol: A Purine Inhibitor of Xanthine Oxidase (XO)
Allopurinol is a xanthine oxidase (XO) inhibitor which inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism. XO catalyzes the oxidative hydroxylation of hypoxanthine [H0311] to xanthine [X0004] and further catalyze the oxidation of xanthine to uric acid [U0018]. Hence, XO inhibitors can lower serum levels of uric acid. In additon, febuxostat [F0847] is a non-purine inhibitor of XO. Allopurinol, first synthesized as a potential antitumor agent, is nowadays a clinical useful XO inhibitor used in the treatment of gout and the prevention of tumor lysis syndrome. (The product is for research purpose only.)
References
- Progress towards the discovery of xanthine oxidase inhibitors (a review)
- Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol (a review)
- Xanthine oxidase inhibition for chronic heart failure: Is allopurinol the next therapeutic advance in heart failure? (a review)
- A high-performance liquid chromatographic method for the determination of hypoxanthine, xanthine, uric acid and allantoin in serum
- Analysis of Purines in Urinary Calculi by High-Performance Liquid Chromatography
- A simple method for quantification of allopurinol and oxipurinol in human serum by high-performance liquid chromatography with UV-detection
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