Dorsomorphin (1) is a potent inhibitor of AMP-activated protein kinase (AMPK).1) AMPK is inhibited by 1 with
Ki = 109 nM. However, 1 does not significantly inhibit structurally related kinases, including spleen tyrosine kinase (SYK), zeta-chain-associated protein kinase (ZAPK), protein kinase A (PKA), protein kinase Cθ (PKCθ), and Janus kinase (JAK).
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AMP-Activated Protein Kinase (AMPK) Inhibitor
No.176(January 2018)
Additionally, 1 inhibits bone morphogenetic protein (BMP) signaling.2) 1 promotes self-renewal of human embryonic stem cells (hESCs).3) Interestingly, 1 can support stem cell self-renewal over the long term (five or more passes).
This product is for research purpose only.
References
- 1)Role of AMP-activated protein kinase in mechanism of metformin action
- 2)Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
- 3)Dorsomorphin promotes human embryonic stem cell self-renewal
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