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CAS RN: 51803-78-2 | Product Number: N0984
Nimesulide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$23.00
|
36 | 0 | Contact Us | |
| 5G |
$66.00
|
17 | 8 | Contact Us |
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| Product Number | N0984 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__2N__2O__5S = 308.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 51803-78-2 |
| Reaxys Registry Number | 2421175 |
| PubChem Substance ID | 253662461 |
| Merck Index (14) | 6548 |
| MDL Number | MFCD00079470 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 148.0 to 152.0 °C |
Properties (reference)
| Melting Point | 150 °C |
| Maximum Absorption Wavelength | 391(H2O) nm |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | PB0970000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2935.90-000 |
Application
比較的選択的なシクロオキシゲナーゼ-2 (COX-2) 阻害剤，ニメスリド
Nimesulide, a sulfonanilide compound, is a relatively selective inhibitor of cyclooxygenase-2 (COX-2) and is used as a non-steroidal anti-inflammatory drug (NSAID). Selective inhibition of COX-2 by NSAIDs may have less gastrointestinal toxicity, while inhibition of COX-1 is linked to gastrointestinal ulcer formation. In addition, nimesulide has some unique therapeutic and pharmacological activities. However, nimesulide induced hepatotoxicity is reported.
References
- In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide. An overview
- Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis
- Nimesulide: some pharmaceutical and pharmacological aspects - an update (a review)
- Nimesulide: an NSAID that preferentially inhibits COX-2, and has various unique pharmacological activities (a review)
- Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide (a review)
- A review of analytical techniques for determination of oxicams, nimesulide and nabumetone
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