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CAS RN: 894-71-3 | Product Number: N0957
Nortriptyline Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine Hydrochloride
- 10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride
Product Documents:
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| 5G |
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3 | 0 | It can be shipped in about 2 weeks after ordering |
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| Product Number | N0957 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__1N·HCl = 299.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 894-71-3 |
| Related CAS RN | 72-69-5 |
| Reaxys Registry Number | 4163872 |
| PubChem Substance ID | 253662334 |
| Merck Index (14) | 6715 |
| MDL Number | MFCD00058024 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 216.0 to 220.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 218 °C |
| Maximum Absorption Wavelength | 237 nm (H__2O) |
| Solubility in water | Slightly soluble |
| Solubility (soluble in) | Ethanol |
| Solubility (insoluble in) | Ether, Benzene, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | HP0175000 |
Transport Information:
| H.S.code* | 2921.49-000 |
Application
三環性抗うつ薬ノルトリプチリン
Nortriptyline hydrochloride is a tricyclic antidepressant. The mechanism of action is currently not clear, but it is assumed that nortriptyline inhibits the reuptake of noradrenaline [A0906] in brain. Nortriptyline is metabolized by P450 enzyme CYP2D6 into trans-10-hydroxynortriptyline which is reported as an active form. Recently, nortriptyline hydrochloride is mainly used for smoking cessation. (The product is for research purpose only.)
References
- Nortriptyline hydrochloride (a review of the physical properties of it)
- 10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
- The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man (a review)
- Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: A multi-level, single-sample approach
- Nortriptyline for smoking cessation: A review
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