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CAS RN: 54527-84-3 | Product Number: N0635
Nicardipine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| Product Number | N0635 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__9N__3O__6·HCl = 515.99 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 54527-84-3 |
| Related CAS RN | 55985-32-5 |
| Reaxys Registry Number | 4286471 |
| PubChem Substance ID | 87573949 |
| Merck Index (14) | 6495 |
| MDL Number | MFCD00057327 |
Specifications
| Appearance | White to Light yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | US7972100 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.39-000 |
Application
水溶性のジヒドロピリジン系L型Ca2+チャンネル受容体アンタゴニスト，ニカルジピン塩酸塩
Nicardipine hydrochloride is a water-soluble dihydropyridine-derivative and a second generation L-type Ca2+ channel receptor antagonist which relaxes arterial smooth muscle with high vascular selectivity and without changing serum calcium concentrations. Nicardipine is mainly metabolized by CYP3A4 in the liver. Nicardipine is also reported to have anti-oxidant activity. (The product is for research purpose only.)
References
- Inhibition of calcium influx in rabbit aorta by nicardipine hydrochloride
- Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]-nitrendipine binding sites
- Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders
- Intravenous nicardipine. Its use in the short-term treatment of hypertension and various other indications (a review)
- Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions
- Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells: correlation of protection with preservation of glutathione levels
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