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CAS RN: 364-62-5 | Product Number: M2218
Metoclopramide
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Purity: >98.0%(GC)(T)
Synonyms:
- 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 5G |
$36.00
|
6 | 0 | Contact Us | |
| 25G |
$109.00
|
11 | 1 | Contact Us |
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| Product Number | M2218 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2ClN__3O__2 = 299.80 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 364-62-5 |
| Related CAS RN | 7232-21-5 |
| Reaxys Registry Number | 1884366 |
| PubChem Substance ID | 468592199 |
| Merck Index (14) | 6143 |
| MDL Number | MFCD00211338 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 147.0 to 151.0 °C |
Properties (reference)
| Melting Point | 149 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.2 g/l 25 °C |
| Solubility (soluble in) | Methanol |
| Solubility (slightly sol. in) | Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | BZ3300000 |
Transport Information:
| H.S.code* | 2924.29-000 |
Application
Metoclopramide: A Centrally Acting Dopamine D2 Receptor Antagonist
Metoclopramide is a centrally acting dopamine D2 receptor antagonist with antiemetic properties similar to those of domperidone [D4125]. Unlike domperidone, however, metoclopramide easily crosses the blood-brain barrier. Its antiemetic effect may be due to a combination of an antagonism of dopamine D2 and 5-HT3 receptors, and gastrokinetic effects by 5-HT4 receptor stimulants. (The product is for research purpose only.)
References
- Metoclopramide: an updated review of its pharmacological properties and clinical use
- The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6
- Development of drugs for gastrointestinal motor disorders: translating science to clinical need (a review)
- Metoclopramide hydrochloride (A review of the chemical and pharmacological determinations)
- Sensitive quantification of chosen drugs by reversed-phase chromatography with electrochemical detection at a glassy carbon electrode
- Novel molecularly imprinted polymers for the selective extraction and determination of metoclopramide in human serum and urine samples using high-performance liquid chromatography
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