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CAS RN: 66335-38-4 | Product Number: D4342
5'-Deoxy-5-fluorocytidine
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 1G |
$28.00
|
20 | 2 | Contact Us | |
| 5G |
$91.00
|
12 | 39 | Contact Us |
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| Product Number | D4342 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2FN__3O__4 = 245.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 66335-38-4 |
| Reaxys Registry Number | 753982 |
| PubChem Substance ID | 253659749 |
| MDL Number | MFCD07369278 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 203.0 to 210.0 °C |
Properties (reference)
| Melting Point | 204 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
5'-Deoxy-5-Fluorocytidine: A Prodrug of Active Antitumor 5-FU
5'-Deoxy-5-fluorocytidine is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine [D3579], to form 5-FU. (The product is for research purpose only.)
References
- Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumors by enzymes concentrated in human liver and cancer tissue
- Clinical pharmacokinetics of capecitabine
- Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver
- Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide
- A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
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