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CAS RN: 6001-74-7 | Product Number: C3020
Chlormethiazole Hydrochloride
Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-(2-Chloroethyl)-4-methylthiazole Hydrochloride
- Clomethiazole Hydrochloride
- Somnevrin Hydrochloride
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Shipping Information |
---|---|---|---|---|---|
200MG |
$101.00
|
12 | 0 | Contact Us | |
1G |
$350.00
|
1 | 0 | It can be shipped in about 4-5 weeks after ordering |
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* The storage conditions are subject to change without notice.
Product Number | C3020 |
Purity / Analysis Method | >98.0%(T)(HPLC) |
Molecular Formula / Molecular Weight | C__6H__8ClNS·HCl = 198.11 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
Store Under Inert Gas | Store under inert gas |
Condition to Avoid | Hygroscopic |
Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
CAS RN | 6001-74-7 |
Related CAS RN | 533-45-9 |
Reaxys Registry Number | 3697289 |
PubChem Substance ID | 253662385 |
Merck Index (14) | 2384 |
MDL Number | MFCD00673948 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Melting point | 134.0 to 138.0 °C |
Properties (reference)
Melting Point | 136 °C |
Solubility in water | Soluble |
Solubility (soluble in) | Alcohol |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
H.S.code* | 2934.10-000 |
Application
Chlormethiazole Hydrochloride: A Neuroprotective and a CYP2E1 Inhibitory Agent
Chlormethiazole hydrochloride is a thiazole derivative with sedative and anticonvulsive properties. The mechanism of action is considered to involve the potentiation of GABA [A0282] activity, the major intrinsic inhibitory neurotransmitter. Chlormethiazole is also reported to inhibit cytochrome P 450 2E (CYP2E1) which is suggested to alcoholic liver disease. (The product is for research purpose only.)
References
- Neuroprotective activity of chlormethiazole following transient forebrain ischemia in the gerbil
- The pharmacology of chlormethiazole: a potential neuroprotective agent? (A review)
- Chlormethiazole as an efficient inhibitor of cytochrome P450 2E1 expression in rat liver
- nhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
PubMed Literature
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