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CAS RN: 10513-45-8 | Product Number: B0832
N-tert-Butyl-5-methylisoxazolium Perchlorate
Purity: >98.0%(HPLC)(N)
Synonyms:
- Woodward's Reagent L
Product Documents:
Size | Unit Price | Same Day | 2-3 Business Days |
---|---|---|---|
1G |
$65.00
|
3 | 1 |
5G |
$213.00
|
4 | 4 |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
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Product Number | B0832 |
Purity / Analysis Method | >98.0%(HPLC)(N) |
Molecular Formula / Molecular Weight | C__8H__1__4ClNO__5 = 239.65 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
CAS RN | 10513-45-8 |
Reaxys Registry Number | 5202574 |
PubChem Substance ID | 87563816 |
SDBS (AIST Spectral DB) | 10455 |
MDL Number | MFCD00011960 |
Specifications
Appearance | White to Light yellow to Light red powder to crystal |
Purity(HPLC) | min. 98.0 area% |
Purity(with Total Nitrogen) | min. 98.0 % |
Melting point | 119.0 to 122.0 °C |
Properties (reference)
Melting Point | 119 °C |
GHS
Pictogram | |
Signal Word | Warning |
Hazard Statements | H272 : May intensify fire; oxidizer. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P220 : Keep/Store away from clothing/ combustible materials. P210 : Keep away from heat. P221 : Take any precaution to avoid mixing with combustibles. P280 : Wear protective gloves/ eye protection/ face protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. |
Related Laws:
Transport Information:
UN Number | UN1479 |
Class | 5.1 |
Packing Group | III |
H.S.code* | 2934.99-000 |
Application
Woodward’s Reagent L: A Condensing Agent
Experimental procedure1):
Under nitrogen, N-tert-butyl-5-methylisoxazolium perchlorate (240 mg, 1 mmol) is added to a mixture of 3-quinoline carboxylic acid (173 mg, 1 mmol) and triethylamine (140 µL, 1 mmol) in DMF (2 mL). The mixture is stirred at room temperature for 4 h and then poured on iced water (50 mL). The precipitate is collected, washed with water and dried. The intermediate ester 1 (131 mg, 0.44 mmol) is isolated in 44% yield as a yellow powder. Then the product (110 mg, 0.36 mmol) in DMF (3 mL) is added to a freshly prepared guanidine 2 (123 mg, 0.39 mmol) and the mixture is stirred at 140 °C for 2 h. The solvent is evaporated under reduced pressure. Water (10 mL) is added to the residue, and after 12 h at 4 °C, the precipitate formed is filtered, washed with water, and dried to obtain compound 3 in 85% yield.
Under nitrogen, N-tert-butyl-5-methylisoxazolium perchlorate (240 mg, 1 mmol) is added to a mixture of 3-quinoline carboxylic acid (173 mg, 1 mmol) and triethylamine (140 µL, 1 mmol) in DMF (2 mL). The mixture is stirred at room temperature for 4 h and then poured on iced water (50 mL). The precipitate is collected, washed with water and dried. The intermediate ester 1 (131 mg, 0.44 mmol) is isolated in 44% yield as a yellow powder. Then the product (110 mg, 0.36 mmol) in DMF (3 mL) is added to a freshly prepared guanidine 2 (123 mg, 0.39 mmol) and the mixture is stirred at 140 °C for 2 h. The solvent is evaporated under reduced pressure. Water (10 mL) is added to the residue, and after 12 h at 4 °C, the precipitate formed is filtered, washed with water, and dried to obtain compound 3 in 85% yield.
References
- 1) Chemical Delivery System of Metaiodobenzylguanidine (MIBG) to the Central Nervous System
- 2) Stable enol esters from N-tert-butyl-5-methylisoxazolium perchlorate
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