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Vitamin C Derivative
No.163(October 2014)
Since Martin successfully isolated and established pluripotent cell lines with the properties of teratocarcinoma stem cells directly from normal early mouse embryos in vitro,1) research on embryonic stem (ES) cells has progressed year after year.
In 2006, S Yamanaka et al. identified factors for inducing pluripotent stem cells from somatic cells.2) Since then, technologies to establish induced pluripotent stem (iPS) cells have been developed.
Recently, ascorbic acid was found to enhance the generation of iPS cells3) and the cardiac differentiation of ES cells4) and iPS cells.5) Ascorbic acid 2-phosphate is a stable derivative of ascorbic acid and has been used as a supplement instead of ascorbic acid.6,7) The application of ascorbic acid 2-phosphate for the field described above has been demonstrated, i.e. serum-free culture,8) feeder-independent culture,9) etc.
References
- 1)Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
- 2)Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
- 3)Vitamin C enhances the generation of mouse and human induced pluripotent stem cells
- 4)Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
- 5)Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells
- 6)L-Ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts
- 7)Effects of ascorbic acid and ascorbic acid 2-phosphate, a long-acting vitamin C derivative, on the proliferation and differentiation of human osteoblast-like cells
- 8)Development of a serum-free system to expand dental-derived stem cells: PDLSCs and SHEDs
- 9)Feeder-independent culture of human embryonic stem cells
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