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Plant Bitter Ingredient
No.161(April 2014)
The bitter principles of genus Swertia can be classified into three groups: iridoid glycosides, secoiridoid glycosides, and biphenyl glycosides.1) Swertiamarin (1) is one of secoiridoid glucosides.1) The main biosynthetic pathway of 1 in the Gentianae is a route which leads from iridodial via deoxyloganic acid or loganic acid to secoiridoids.2) It has been numerously reported that 1 shows anti-inflammatory,3) anti-hyperlipidaemic,4) anti-nociceptive,4) hepatoprotective,4) anti-diabetic5,6) effects, etc.
References
- 1)Systematic review on xanthones and others isolates from genus Swertia
- 2)Chemotaxonomy and pharmacology of Gentianaceae
- S. R. Jensen, J. Schripsema, in Gentianaceae: Systematics and Natural History, eds. by L. Struwe, V. A. Albert, Cambridge University Press, Cambridge, 2002, pp. 573-631.
- 3)Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3
- 4)Naturally occurring iridoids, secoiridoids. An updated review, part 4
- 5)Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin
- 6)Glycogen phosphorylase-a is a common target for anti-diabetic effect of iridoid and secoiridoid glycosides
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