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HDAC Inhibitor
No.157(April 2013)
Suberoylanilidehydroxamic acid (SAHA, 1) is a histone deacetylase (HDAC) inhibitor1,2) and inhibits both classes I and II enzymes by binding to the pocket of the catalytic site.3) 1 is one of the hydroxamic acid-based hybrid polar compounds because it has in common two polar groups separated by an apolar 5- to 6-carbon methylene chain.2) 1 has been demonstrated to inhibit the proliferation of a wide variety of transformed cells in vitro.1)
References
- 1)Cancer biology: mechanism of antitumor action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor
- 2)A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
- 3)Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
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