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W-13 Hydrochloride: A Calmodulin Inhibitor
No.154(November 2014)
W-13 hydrochloride (1) is a well-known cell-permeable and reversible calmodulin inhibitor used to study calmodulin regulation of the intracellular Ca2+ signaling-related process.1-3)
References
- 1)Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
- 2)Inhibition of volume-activated I- and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition
- 3)Membrane-permeable calmodulin inhibitors bind to membranes, changing the electrostatic surface potential: Dual effect of W-13 on epidermal growth factor receptor activation
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