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CAS RN: 153437-55-9 | 產品號碼: W0021
WHI-P180 Hydrochloride
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| 產品號碼 | W0021 |
| 純度/分析方法 | >97.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__6H__1__5N__3O__3·HCl = 333.77 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic |
| CAS RN | 153437-55-9 |
| Reaxys-RN | 8592187 |
| PubChem Substance ID | 468593126 |
| MDL編號 | MFCD09026915 |
產品規格
| Appearance | White to Light gray to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Water | max. 2.0 % |
| NMR | confirm to structure |
性質
GHS
相關法規
運輸資料
| HS編碼* | 2933.59-000 |
Application
WHI-P180 Hydrochloride: A Multi-Kinase Inhibitor
WHI-P180 (hydrochloride) is a multi-kinase inhibitor. There are reports that it inhibits rearranged during transfection (RET) kinase and kinase insert domain receptor (KDR), respectively.1) It also inhibits epidermal growth factor receptor (EGFR) as well as Janus Kinase 3 (JAK3).2,3) It inhibits IgE/antigen-induced vascular hyper-permeability,4) and cyclin-dependent kinase 2 (CDK2).5) In addition, it binds to tau-tubulin kinase 1 (TTBK1).6) (The product is for research purpose only.)
References
- 1) The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity
- 2) 4-[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride
- 3) Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor
- 4) Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice
- 5) Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase
- 6) X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors
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