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CAS RN: 330808-88-3 | 產品號碼: V0174
Vardenafil Hydrochloride Trihydrate
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| 產品號碼 | V0174 |
純度/分析方法
|
>95.0%(T)(HPLC) |
| 分子式 / 分子量 | C__2__3H__3__2N__6O__4S·HCl·3H__2O = 579.12 |
| 外觀與形狀(20°C) | Solid |
儲存條件
|
Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 330808-88-3 |
| Reaxys-RN | 15521289 |
| MDL編號 | MFCD08458876 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Precipitation Titration) | min. 95.0 % |
| Water | 7.5 to 10.0 % |
| NMR | confirm to structure |
性質
| 水溶性 | Slightly soluble |
| 溶解性(微溶於) | Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | NJ6154000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2935.90-000 |
Application
Vardenafil: A Selective PDE5 Inhibitor
Vardenafil hydrochloride is a selective inhibitor of 3’,5’-cyclic guanosine monophosphate (cGMP) - specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa, as with sildenafil [S0986 (Citrate)].1,2) In addition, recently PDE5 inhibitors, including tadalafil, are widely used for the treatment of pulmonary arterial hypertension (PAH) which is a progressive disease that ultimately causes right heart failure and death.3) (The product is for research purpose only.)
References
- 1) The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
- 2) Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil review of the literature (a review)
- 3) Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets
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