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CAS RN: 52-24-4 | 產品號碼: T4184
| 產品號碼 | T4184 |
| 純度/分析方法 | >95.0%(HPLC) |
| 分子式 / 分子量 | C__6H__1__2N__3PS = 189.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 250MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 52-24-4 |
| Reaxys-RN | 145978 |
| MDL編號 | MFCD00145452 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 52.0 to 56.0 °C |
| Water | max. 2.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 54 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. H360 : May damage fertility or the unborn child. H371 : May cause damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H340 : May cause genetic defects. H350 : May cause cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | SZ2975000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | II |
| HS編碼* | 2933.99-000 |
Application
Thiotepa: An Alkylating Cytotoxic Agent with a Broad Spectrum of Antitumor Activity
Thiotepa (ThioTEPA) is a trifunctional alkylating cytotoxic agent with a broad spectrum of antitumor activity. It is thought to inhibit tumor growth by inhibiting DNA synthesis.1) The major DNA bond cleavages are initiated by alkylation of guanine and adenine at the N-7 position, which breaks the bond between the purine base and the sugar, releasing alkylated guanines and adenines.2) (The product is for research purpose only.)
References
- 1) Chemistry, pharmacology and pharmacokinetics of N,N',N" - triethylenethiophosphoramide triethylenethiophosphoramide (ThioTEPA) (a review)
- 2) Density Functional Theory Investigation of the Binding of ThioTEPA to Purine Bases: Thermodynamics and Bond Evolution Theory Analysis
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