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CAS RN: 13957-31-8 | 產品號碼: T4059
產品號碼 | T4059 |
純度/分析方法 | >95.0%(qNMR) |
分子式 / 分子量 | C__9H__1__2N__2O__5S = 260.26 |
外觀與形狀(20°C) | Solid |
儲存條件 | Frozen (-20°C) |
儲存在惰性氣體下 | Store under inert gas |
應避免的情況 | Air Sensitive,Heat Sensitive |
包裝和容器 | 100MG-Glass Bottle with Plastic Insert (閲覽圖片) |
CAS RN | 13957-31-8 |
Reaxys-RN | 28750 |
MDL編號 | MFCD00006538 |
產品規格
Appearance | White to Light yellow powder to crystal |
Purity(qNMR) | min. 95.0 % |
NMR | confirm to structure |
性質
熔點 | 140 °C |
GHS
相關法規
運輸資料
HS編碼* | 2934.99-000 |
Application
4-Thiouridine: A Photoactive Ribonucleoside Analog Used for RNA Analysis Methods
4-Thiouridine (s4U or 4sU) is a photoactive ribonucleoside analog found in transfer RNA (tRNA), and absorbs light at wavelengths longer than 320 nm and, thus, can be selectively photo-activated.1,2) Recently, 4-thiouridine has been widely used for RNA analysis methods based on the photo-activity, such as PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation)3-5) and SLAM seq (thiol (SH)-linked alkylation for the metabolic sequencing of RNA)6). (The product is for research purpose only.)
References
- 1) Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions (a review)
- 2) Site-specific RNA crosslinking with 4-thiouridine (a review)
- 3) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
- 4) PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 5) Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 6) Thiol-linked alkylation of RNA to assess expression dynamics
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