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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 13647-35-3 | 產品號碼: T4049
| 產品號碼 | T4049 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__0H__2__7NO__3 = 329.44 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 13647-35-3 |
| Reaxys-RN | 7043886 |
| MDL編號 | MFCD00199295 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +135 to +150 deg(C=1, pyridine) |
| NMR | confirm to structure |
性質
| 水溶性 | Insoluble |
| 溶解性（微溶於） | Dimethylformamide |
| 溶解性（不溶於） | Chloroform, Diethyl ether |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | BV8044200 |
運輸資料
| HS編碼* | 2937.29-000 |
Application
Trilostane: A Reversible and Competitive Inhibitor of 3β-Hydroxysteroid Dehydrogenase (3β-HSD)
Trilostane is a reversible and competitive inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD), which is the key enzyme essential for synthesis of cortisol and all other steroids. 3β-HSD has two isozymes, type1 (3β-HSD1) and type2 (3β-HSD2). 3β-HSD1 is a critical enzyme in the conversion of DHEA [D0044] to estradiol [E0919] in breast tumor cells and may be a target enzyme for inhibition in the treatment of breast cancer, whereas 3β-HSD2 participates in the production of cortisol and aldosterone in the adrenal gland.1,2) Trilostane is an inhibiter of the 3β-HSDs (type 1 and 2). Therefore, trilostane is of interest for the treatment of breast cancer in postmenopausal women2), and has been used for the treatment of Cushing's syndrome in dogs to reduce cortisol and aldosterone levels.3,4) (The product is for research purpose only.)
References
- 1) Structure/function of the inhibition of human 3β-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane
- 2) Selective inhibition of human 3β-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer (a review)
- 3) Aldosterone-, Corticosterone- and Cortisol-Secreting Adrenocortical Carcinoma in a Dog: Case Report
- 4) Treating canine Cushing's syndrome: Current options and future prospects (a review)
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