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CAS RN: 62996-74-1 | 產品號碼: T4000
| 產品號碼 | T4000 |
| 純度/分析方法 | >98.0%(HPLC) |
| 分子式 / 分子量 | C__2__8H__2__6N__4O__3 = 466.54 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 10MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 62996-74-1 |
| Reaxys-RN | 6674025 |
| PubChem Substance ID | 468593064 |
| MDL編號 | MFCD18252446 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +71.0 to +75.0 deg(C=0.1, ﾒﾀﾉｰﾙ) |
| NMR | confirm to structure |
性質
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
| RTECS # | KC6550000 |
運輸資料
| HS編碼* | 2941.90-000 |
Application
Staurosporine: A Potent Inhibitor of Protein Kinase
Staurosporine (AM-2282) is an indolocarbazole antibiotic originally isolated from the bacterium Streptomyces staurosporeus by Omura et al. in 1977.1) It has been reported that staurosporine and display strong inhibitory effect against a variety of kinases including protein kinase C (PKC), and a number of biological properties such as antifungal, antibacterial, and apoptosis-inducing activities1,2). Staurosporine also inhibits wild-type LRRK2 (leucine-rich repeat kinase 2), which is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity.3) Nevertheless, staurosporine is poorly selective against other protein kinases. To obtain specific PKC inhibitors, a number of its analogues has been developed.4,5) (The product is for research purpose only.)
References
- 1) Staurosporine, a Potentially Important Gift from a Microorganism (a review)
- 2) Induction of a common pathway of apoptosis by staurosporine
- 3) Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
- 4) Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (a review)
- 5) Protein kinase inhibition of clinically important staurosporine analogues (a review)
TCIMail
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