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CAS RN: 56776-01-3 | 產品號碼: T2954
Tulobuterol Hydrochloride
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| 產品號碼 | T2954 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__2H__1__8ClNO·HCl = 264.19 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 56776-01-3 |
| 相關CAS RN | 41570-61-0 |
| Reaxys-RN | 5646719 |
| PubChem Substance ID | 253662260 |
| Merck Index(14) | 9811 |
| MDL編號 | MFCD00214398 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 159.0 to 164.0 °C |
性質
| 熔點 | 160 °C |
| 溶解性（可溶於） | Acetone |
| 溶解性（不溶於） | Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | DN8785000 |
運輸資料
| HS編碼* | 2922.19-000 |
Application
Tulobuterol: A β2-Adrenergic Receptor Agonist
Tulobuterol is a β2-adrenergic receptor agonist to induce relaxation of airway smooth muscle cells. The mechanism of action is explained as follows. Occupation of β2-adrenergic receptors by tulobuterol results in the activation of the adenylyl cyclase (AC), leading to an increase in intracellular cyclic AMP [A2381] and activation of protein kinase A (PKA). PKA phosphorylates Ca2+-ATPase, resulting in opening of Ca2+-activated K+ channels, decreasing intracellular Ca2+ concentration, and also decreased myosin light chain kinase (MLCK) activity. Tulobuterol transdermal patch as a controlled-release drug delivery system is used for medical purposes. (The product is for research purpose only.)
References
- Quantitative evaluation of the β2-adrenoceptor intrinsic activity of N-tert-butylphenylethanolamines
- Determination of β-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry
- Pulmonary Pharmacology
- L. L. Brunton, B. A. Chabner, B. C. Knollmann, Goodman & Gilman’s The Pharmacological Basis of Therapeutics 12th edition, USA McGraw Hill Inc., 2011.
- Transdermal Tulobuterol Patch, a Long-Acting β2-Agonist (a review)
考研文獻
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