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CAS RN: 70024-40-7 | 產品號碼: T2751
Terazosin Hydrochloride Dihydrate
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| 產品號碼 | T2751 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__1__9H__2__5N__5O__4·HCl·2H__2O = 459.93 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 70024-40-7 |
| 相關CAS RN | 63590-64-7&63074-08-8 |
| Reaxys-RN | 6495493 |
| PubChem Substance ID | 125307764 |
| MDL編號 | MFCD00941408 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Water | 7.0 to 9.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 274 °C |
GHS
相關法規
| RTECS # | TK8046000 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
Terazosin Hydrochloride: A Long Acting α1-Selective Adrenoceptor Antagonist
Terazosin hydrochloride, a quinazoline derivative, is a long acting α1-selective adrenoceptor antagonist with a similar pharmacodynamic profile to prazosin [P0938]. Terazosin is known to relax vascular and prostate smooth muscle through blockade of α1-adrenoceptors, and lowers blood pressure by decreasing peripheral vascular resistance. In in vitro experiments, terazosin has been shown to contractions in human prostatic tissue, and it is used in the treatment for prostatic hyperplasia (BPH). In addition, some studies indicate that α1-selective adrenoceptor antagonists show suppression of human prostate cancer cell growth. (The product is for research purpose only.)
References
- Adrenergic and serotonergic receptor-blocking potencies of terazosin, a new antihypertensive agent, as assessed by radioligand binding assay
- Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension
- Binding characteristics of naftopidil and α1-adrenoceptor antagonists to prostatic α-adrenoceptors in benign prostatic hypertrophy
- Suppression of human prostate cancer cell growth by α1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis
- Terazosin (The description, physical properties, synthesis, stability, pharmacokinetics, metabolism and analysis of terazosin)
- Validated specific HPLC methods for determination of prazosin, terazosin, and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions
考研文獻
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