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CAS RN: 67-03-8 | 產品號碼: T0181
Thiamine Hydrochloride
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補充產品訊息:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| 產品號碼 | T0181 |
純度/分析方法 
|
>98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__2H__1__7ClN__4OS·HCl = 337.26 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Hygroscopic |
| CAS RN | 67-03-8 |
| 相關CAS RN
|
129659-07-0 |
| Reaxys-RN | 3851771 |
| PubChem Substance ID | 87576174 |
| Merck Index(14) | 9295 |
| MDL編號 | MFCD00012780 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Solubility in Water | almost transparency |
| Water | max. 5.0 % |
性質
GHS
相關法規
| RTECS # | XI7350000 |
運輸資料
| HS編碼* | 2936.22-000 |
Application
Thiamine (Vitamin B1): One of Essential B Vitamins with Many Important Functions in All Tissues
Thiamine, also known as vitamin B1, is one of essential B vitamins that has many important functions in all tissues.1-3) Two types of water soluble thiamine salts, thiamine hydrochloride [T0181] and thiamine nitrate [T0182], are commonly used to products.4) Thiamine pyrophosphate (diphosphate) chloride [T0183] is the biologically active form of thiamine. In addition, thiamine hydrochloride is also used as an efficient catalyst for chemical reactions.7,8) For your reference, [A2633] is a key synthetic intermediate of thiamin. (The product is for research purpose only.)
References
- 1) Thiamin biosynthesis in prokaryotes (a review)
- 2) Molecular mechanisms of thiamine utilization (a review)
- 3) The structural and biochemical foundations of thiamin biosynthesis (a review)
- 4) Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution
- 5) Analytical profile of thiamin hydrochloride (a review of the preparation, physical properties, metabolism, methods of determination, etc., of thiamin)
- 6) Determination of thiamine by high-performance liquid chromatography
- 7) Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols
- 8) Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium
Application
Synthesis of Formamide Derivatives Catalyzed by Vitamin B1 Hydrochloride
N-Formination of aniline using VB1 as a catalyst:
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
References
- A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst
Application
Thiamine Catalyzed Benzoin Condensation: Synthesis of Fluorobenzoins
Typical procedure : Synthesis of 4,4’-Difluorobenzoin
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
References
PubMed Literature
文檔
產品介紹報導
[Product Highlights] Synthesis of Formamide Derivatives Catalyzed by Vitamin B1 Hydrochloride產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
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