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CAS RN: 5690-03-9 | 產品號碼: S0892
| 產品號碼 | S0892 |
| 純度/分析方法 | >98.0%(GC) |
| 分子式 / 分子量 | C__1__3H__1__0O__2 = 198.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 5690-03-9 |
| Reaxys-RN | 161649 |
| PubChem Substance ID | 172089098 |
| MDL編號 | MFCD08705254 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 53.0 to 57.0 °C |
性質
| 熔點 | 55 °C |
GHS
相關法規
運輸資料
| HS編碼* | 2932.20-000 |
Application
Splitomicin: A Potent Selective Inhibitor of Silent Information Regulator-2 (Sir2)
Silent Information Regulator-2 (Sir2) is a one of Class III histone deacetylases (HDACs) called Sirtuins. Splitomicin, which is derived from β-naphthol, is a potent selective inhibitor of Sir2. It inhibits nicotinamide adenine dinucleotide+ (NAD+) dependent histone deacetylase activity of Sir2.
References
- Identification of a small molecule inhibitor of Sir2p
- Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast
- Inhibitors of Sir2: Evaluation of Splitomicin Analogues
- Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release
- Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway
考研文獻
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