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CAS RN: 103628-48-4 | 產品號碼: S0851
Sumatriptan Succinate
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| 產品號碼 | S0851 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__4H__2__1N__3O__2S·C__4H__6O__4 = 413.49 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 103628-48-4 |
| 相關CAS RN | 103628-46-2 |
| Reaxys-RN | 5371868 |
| PubChem Substance ID | 160871034 |
| Merck Index(14) | 8997 |
| MDL編號 | MFCD00902856 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 165.0 to 169.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 167 °C |
| 水溶性 | Soluble |
| Degree of solubility in water | 170 g/l 24 °C |
| 溶解性（不溶於） | Ether, Ethanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H318 : Causes serious eye damage. |
| 防範說明 | P280 : Wear eye protection/ face protection. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
相關法規
| RTECS # | EJ9940000 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Sumatriptan Succinate: A Selective 5-HT1B/1D Receptor Agonist
Sumatriptan succinate is a selective 5-HT1B/1D receptor agonist, belongs to triptans. Sumatriptan binds with high affinity to 5-HT1 receptor subtypes (5-HT1B, 5-HT1D), but has only a week affinity for a serotonergic receptor subtype (5-HT1A) and has no significant affinity for serotonergic receptor subtypes (5-HT1c, 5-HT2, 5-HT3) or for adrenergic (α1, α2, β), dopamine (D1, D2), muscarinic, or benzodiazepine receptors. Animal studies shows that sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system. In addition, the transdermal iontophoretic patch of sumatriptan succinate is developed. (The product is for research purpose only.)
References
- Comparative Neuropharmacology of Dihydroergotamine and Sumatriptan (GR 43175)
- Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine(a review)
- Triptans in migraine: A comparative review of pharmacology, pharmacokinetics and efficacy
- Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate
- In vitro and in vivo evaluation of the transdermal iontophoretic delivery of sumatriptan succinate
- Review of Analytical Methods for Identification and Determination of Triptans (a review)
考研文獻
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