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CAS RN: 599-79-1 | 產品號碼: S0580
產品規格
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 95.0 % |
性質
| 熔點 | 246 °C(dec.) |
| 水溶性 | Insoluble |
| 溶解性（微溶於） | Alcohol |
| 溶解性（不溶於） | Ether, Benzene, Chloroform |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H351 : Suspected of causing cancer. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
相關法規
| RTECS # | VO6250000 |
運輸資料
| HS編碼* | 2935.90-000 |
Application
Sulfasalazine: A Prodrug of 5-Aminosalicylic Acid (5-ASA), a NF-κB Inhibitor and an xCT Inhibitor
Sulfasalazine (salazosulfapyridin) is formed by combining sulfapyridine and salicylate with an azo bond. Sulfasalazine is split by intestinal bacteria to two main matabolites, sulfapyridine [S0071] and 5-aminosalicylic acid (5-ASA) [A0317], and the 5-ASA shows anti-inflammatory effects. Sulfasalazine is used as a gastrointestinal anti-inflammatory agent and is known as a potent inhibitor of NF-κB. Sulfasalazine is commonly used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease (CD) and rheumatoid arthritis (RA).
Recently, the antitumor effects of sulfasalazine have attracted attention. CD44v is an adhesion molecule expressed in cancer stem-like cells. CD44v interacts with xCT, a glutamate-cysteine transporter, keeping high levels of the intracellular reduced glutathione (GSH) which an important antioxidant and stabilizer in cell. Sulfasalazine works as an xCT inhibitor, and suppresses CD44v-dependent tumor growth and increases sensitivity to cytotoxic drugs. (The product is for research purpose only.)
Recently, the antitumor effects of sulfasalazine have attracted attention. CD44v is an adhesion molecule expressed in cancer stem-like cells. CD44v interacts with xCT, a glutamate-cysteine transporter, keeping high levels of the intracellular reduced glutathione (GSH) which an important antioxidant and stabilizer in cell. Sulfasalazine works as an xCT inhibitor, and suppresses CD44v-dependent tumor growth and increases sensitivity to cytotoxic drugs. (The product is for research purpose only.)
References
- An experiment to determine the active therapeutic moiety of sulphasalazine
- Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazin
- The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites
- Salicylates for ulcerative colitis - their mode of action (a review)
- Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
- Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β
- Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x-c cystine transporter: A new action for an old drug
- xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
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