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CAS RN: 57-24-9 | 產品號碼: S0249
Strychnine
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| 包裝 | 價格 | 同一天 | 2-3个工作日 | 左側以上貨期 |
貨期資訊
|
|---|---|---|---|---|---|
| 25G |
NT$3,160
|
8 | 7 | 下單後約2週內可以出貨 |
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產品規格
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -100 to -108 deg(C=0.25, EtOH) |
| NMR | confirm to structure |
性質
| 比旋光 [α]D | -108° (C=0.25,EtOH) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 160 mg/l 25 °C |
| 溶解性（可溶於） | Chloroform |
| 溶解性（微溶於） | Acetone |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H300 : Fatal if swallowed. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H410 : Very toxic to aquatic life with long lasting effects. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P391 : Collect spillage. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | WL2275000 |
運輸資料
| UN編號 | UN1692 |
| 類別 | 6.1 |
| 包裝類別 | I |
| HS編碼* | 2939.79-000 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
Application
Reagents convulsion or paralysis model
References
- Voltage clamp study of cat spinal motoneurons during strychnine-induced seizures
- Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine
- Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice
- Glycine potentiates strychnine-induced convulsions: role of NMDA receptors
- Strychnine-induced seizures in mice: the role of noradrenaline
- Effects of MK-801 (dizocilpine) and ketamine on strychnine-induced convulsions in rats: comparison with benzodiazepines and standard anticonvulsants
- H. Kubová, P. Mares, Physiol. Res. 1994, 43, 313.
- L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice
- Effect of bis(acetato)tetrakis(imidazole) copper(II) in delaying the onset and reducing the mortality rate of strychnine- and thiosemicarbazide- induced convulsions
考研文獻
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