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CAS RN: 155213-67-5 | 產品號碼: R0116
補充產品訊息:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| 產品號碼 | R0116 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__3__7H__4__8N__6O__5S__2 = 720.95 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片）, 200MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 155213-67-5 |
| Reaxys-RN | 7680098 |
| PubChem Substance ID | 253660208 |
| Merck Index(14) | 8238 |
| MDL編號 | MFCD00927142 |
產品規格
| Appearance | White to Almost white powder to crystaline |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 122.0 to 127.0 °C |
| Specific rotation [a]20/D | +7.0 to +10.0 deg(C=2,MeOH) |
性質
| 熔點 | 125 °C |
| 比旋光 [α]D | 8° (C=2,MeOH) |
| 水溶性 | Insoluble |
| 溶解性（微溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
相關法規
| RTECS # | XA5310000 |
運輸資料
| HS編碼* | 2934.10-000 |
Application
Ritonavir: a Booster of Other Protease Inhibitors
Ritonavir was originally developed as an inhibitor of HIV protease inhibitor (PI). Ritonavir is currently exclusively used as a pharmacokinetic enhancer (booster) of other protease inhibitors, due to ritonavir's potent inhibition of the cytochrome P 450 3A4 (CYP3A4), an enzyme that is responsible for metabolizing most HIV PIs.
References
- A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
- A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
- Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
- Pharmacokinetic enhancers for HIV drugs
- M. W. Hull, J. S. G. Montaner, Curr. Opin. Invest. Drugs 2009, 10, 775.
- Ritonavir-boosted protease inhibitors in HIV therapy
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