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CAS RN: 129101-54-8 | 產品號碼: R0093
Rivastigmine L-Tartrate
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| 包裝 | 價格 | 同一天 | 2-3个工作日 |
|---|---|---|---|
| 1G |
NT$7,080
|
≥40 | 39 |
| 5G |
NT$23,680
|
25 | 22 |
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
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| 產品號碼 | R0093 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__4H__2__2N__2O__2·C__4H__6O__6 = 400.43 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 129101-54-8 |
| 相關CAS RN | 123441-03-2 |
| PubChem Substance ID | 135727179 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 124.0 to 128.0 °C |
| Specific rotation [a]20/D | +4.0 to +7.0 deg(C=5, methanol) |
性質
| 熔點 | 126 °C |
| 比旋光 [α]D | 5° (C=5,MeOH) |
| 溶解性（可溶於） | Methanol |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | FA9550000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2924.29-000 |
Application
Rivastigmine Tartrate: A Dual Inhibitor of Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE)
Rivastigmine tartrate is an inhibitor of two cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Rivastigmine activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by AChE and BuChE. For comparison, another cholinesterase inhibitor, donepezil hydrochloride [D4099] shows high selectivity for AChE over BuChE.. Rivastigmine tartrate is used for the treatment of Alzheimer’s disease. For your reference, [D5326] is a synthetic intermediate of rivastigmine L-tartrate. (The product is for research purpose only.)
References
- Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
- Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine
- Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
- A review of rivastigmine: a reversible cholinesterase inhibitor
- A stability indicating LC method for Rivastigmine hydrogen tartrate
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