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CAS RN: 56-54-2 | 產品號碼: Q0006
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 85.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 169.0 to 174.0 °C |
| Specific rotation [a]20/D | +260 to +275 deg(C=1, EtOH) |
| NMR | confirm to structure |
性質
| 熔點 | 172 °C |
| 比旋光 [α]D | 268° (C=1,EtOH) |
| 水溶性 | Insoluble |
| Degree of solubility in water | 140 mg/l 25 °C |
| 溶解性（可溶於） | Benzene, Alcohol, Chloroform |
| 溶解性（微溶於） | Ether |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | VA4725000 |
運輸資料
| UN編號 | UN2811 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2939.20-000 |
Application
Quinidine: A Class 1a Antiarrhythmic Agent
Quinidine, a cinchona alkaloid, originally derived from the bark of the Cinchona tree. Quinidine is a class 1a antiarrhythmic agent which interferes both with the sodium (Na+) and potassium (K+) channels, with a pharmacological profile of action similar to that of disopyramide [D2793]. Quinidine inhibits the fast inward sodium current, and depresses the conduction velocity. Consequently, quinidine decreases myocardial excitability. Its sulfate [Q0010] is used clinically. (The product is for research purpose only.)
References
- Quinidine (a review)
- Quinidine revisited (a review)
- Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs (a review)
考研文獻
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