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CAS RN: 88150-62-3 | 產品號碼: P2406
Phthaloyl Amlodipine
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纯度/分析方法: >98.0%(HPLC)(N)
別名
- 4-(2-Chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester
- 3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-(1,3-dioxoisoindolin-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
文件：
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| 產品號碼 | P2406 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__2__8H__2__7ClN__2O__7 = 538.98 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Frozen (-20°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Moisture Sensitive,Heat Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 88150-62-3 |
| Reaxys-RN | 6026908 |
| PubChem Substance ID | 468592595 |
| MDL編號 | MFCD07782096 |
產品規格
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 152 °C |
GHS
| 危險性說明 | H413 : May cause long lasting harmful effects to aquatic life. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
相關法規
運輸資料
| HS編碼* | 2933.39-000 |
Application
An Impure Substance in the Synthesis of Amlodipine Besylate
This product has been reported as an impure substance in the synthesis of amlodipine besylate [A2353] which is a long-acting dihydropyridine-type calcium channel antagonist or blocker (CCB) used for the treatment of hypertension and cardiovascular disease.
References
- Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents
- Sources of impurities - investigation of 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[(2-phthalimidoethoxy)methyl]-1,4-dihydropyridine traces formation during the synthesis of amlodipine besylate
- Identification and characterization of potential impurities of amlodipine maleate
- Enantiomeric separation of amlodipine and its two chiral impurities by nano-liquid chromatography and capillary electrochromatography using a chiral stationary phase based on cellulose tris(4-chloro-3-methylphenylcarbamate)
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