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CAS RN: 191217-81-9 | 產品號碼: P2073
Pramipexole Dihydrochloride Monohydrate
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| 產品號碼 | P2073 |
| 純度/分析方法 | >98.0%(HPLC)(N) |
| 分子式 / 分子量 | C__1__0H__1__7N__3S·2HCl·H__2O = 302.26 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 191217-81-9 |
| 相關CAS RN | 104632-25-9&104632-26-0 |
| Reaxys-RN | 14116907 |
| PubChem Substance ID | 253659970 |
| Merck Index(14) | 7705 |
| MDL編號 | MFCD02183927 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -65.0 to -71.0 deg(C=1,MeOH) |
| Water | 5.0 to 7.0 % |
性質
| 熔點 | 290 °C(dec.) |
| 比旋光 [α]D | -67° (C=1,MeOH) |
| 水溶性 | Soluble |
| 溶解性（可溶於） | Methanol |
| 溶解性（不溶於） | dichloromethane |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. H336 : May cause drowsiness or dizziness. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | DL3375000 |
運輸資料
| HS編碼* | 2934.20-000 |
Application
A Dopamine D3 Receptor Agonist, Pramipexole
Pramipexole [P2879] and its dihydrochloride are non-ergot dopamine agonists with high relative specificity and full intrinsic activity at the D2 subfamily (D2, D3, D4) of dopamine receptors. The affinity for the D3 receptor subtype is the highest. Specifically, pramipexoles have selective affinity for the D2 subfamily (D2, D3, D4), with a 7-10 fold greater affinity for D3 than for D2 receptor subtypes; affinity for the D4 receptor subtype is 17-fold less than for D3 receptors. In clinical, the dihydrochloride is used for the treatment of Parkinson's disease. Although the precise mechanism of action is unknown, it is believed to be related to its ability to stimulate dopamine receptors in the striatum. (The product is for research purpose only.)
References
- Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors
- Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist
- Mechanisms of action of pramipexole: Effects on receptors
- M. Dziedzicka-Wasylewska, F. Ferrari, R. D. Johnson, J. Mierau, Z. Rogoz, G. Skuza, P. Sokoloff, Rev. Contemp. Pharmacother. 2003, 12, 1.
- Mechanisms of action of pramipexole: putative neuroprotective effects
- J. P. Bennett Jr., P. M. Carvey, T. R. Hinds, R. D. Johnson, W. Le, W. Phillips, V. H. Sethy, F. F. Vincenzi, M. B. H. Youdim, Rev. Contemp. Pharmacother. 2003, 12, 33.
- Pharmacokinetic evaluation of pramipexole
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