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CAS RN: 318-98-9 | 產品號碼: P0995
Propranolol Hydrochloride
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| 產品號碼 | P0995 |
| 純度/分析方法 | >99.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__6H__2__1NO__2·HCl = 295.81 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Hygroscopic |
| CAS RN | 318-98-9 |
| 相關CAS RN | 525-66-6 |
| Reaxys-RN | 4164259 |
| PubChem Substance ID | 87575108 |
| Merck Index(14) | 7840 |
| MDL編號 | MFCD00012558 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Melting point | 163.0 to 168.0 °C |
| Solubility in hot Water | almost transparency |
性質
| 熔點 | 166 °C |
| 水溶性 | Soluble |
| 溶解性（可溶於） | Alcohol |
| 溶解性（不溶於） | Ether, Benzene |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H302 : Harmful if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
相關法規
| RTECS # | UB7525000 |
運輸資料
| HS編碼* | 2922.19-000 |
Application
Propranolol Hydrochloride: A Non-Selective and Catecholamine Competitive β-Adrenergic Receptor Antagonist
Propranolol hydrochloride is a non-selective and competitive catecholamine β-adrenergic receptor antagonist. Propranolol blocks β1 (myocardial)- and β2(pulmonary, vascular and uterine)-adrenergic receptor site. There are two enantiomers of propranolol, and it is reported that the S-enantiomer blocks β-adrenergic receptors. The mechanism of the antihypertensive effects of propranolol has not been clearly established. However, propranolol may reduce the oxygen requirement of the heart at any level of effort by blocking catecholamine (such as dopamine [A0305], noradrenaline [A0906] and adrenaline [A0173])-induced increases in the heart rate, systolic blood pressure and the velocity and extent of myocardial contraction. (The product is for research purpose only.)
References
- Some effects of propranolol on the central nervous system
- Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites
- Plasma Propranolol Levels in the Quantitative Assessment of β-adrenergic Blockade in Man
- Stereoselective vascular effects of the (R)- and (S)-enantiomers of propranolol and atenolol
- Enantioselective bioanalysis of beta-blocking agents: focus on atenolol, betaxolol, carvedilol, metoprolol, pindolol, propranolol and sotalol
Application
Reagent for cardiomyopathy model
References
- The beneficial effect of amrinone on acute drug-induced heart failure in the anaesthetised dog
- Levosimendan as a rescue drug in experimental propranolol-induced myocardial depression: a randomized study
考研文獻
文章/手冊
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