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CAS RN: 54-71-7 | 產品號碼: P0434
Pilocarpine Hydrochloride
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| 產品號碼 | P0434 |
| 純度/分析方法 | >98.0%(T)(HPLC) |
| 分子式 / 分子量 | C__1__1H__1__6N__2O__2·HCl = 244.72 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 應避免的情況 | Light Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 54-71-7 |
| Reaxys-RN | 4034491 |
| PubChem Substance ID | 87574632 |
| Merck Index(14) | 7424 |
| MDL編號 | MFCD00012722 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 201.0 to 205.0 °C |
| Specific rotation [a]20/D | +89.0 to +94.0 deg(C=2, H2O) |
| Solubility in Water | almost transparency |
性質
| 熔點 | 203 °C |
| 比旋光 [α]D | 92° (C=2,H2O) |
| 溶解性（不溶於） | Ether, Chloroform |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 + H331 : Toxic if swallowed or if inhaled. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P311 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
相關法規
| RTECS # | TK1450000 |
運輸資料
| UN編號 | UN1544 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2939.79-000 |
Application
Pilocarpine Hydrochloride: A Muscarinic Acetylcholine Receptor Agonist
Pilocarpine is an imidazole alkaloid contained in the leaves of Pilocarpus jaborandi and Pilocarpus microphyllus distributed throughout South America. It is a direct acting cholinergic parasympathomimetic agent which acts through direct stimulation of muscarinic acetylcholine receptors (M1, M2, and M3) with low affinity for nicotine receptors. In clinical, formulations of pilocarpine hydrochloride have been used for the treatment of elevated intraocular pressure and dry mouth. (The product is for research purpose only.)
References
- Human M1-, M2- and M3-muscarinic cholinergic receptors: Binding characteristics of agonists and antagonists
- Oral pilocarpine: a review of its pharmacological properties and clinical potential in xerostomia (a review)
考研文獻
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