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CAS RN: 61-25-6 | 產品號碼: P0016
Papaverine Hydrochloride
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產品規格
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
性質
| 熔點 | 225 °C(dec.) |
GHS
| 圖形表示 |
|
| 信號詞 | Danger |
| 危險性說明 | H301 : Toxic if swallowed. |
| 防範說明 | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
相關法規
| RTECS # | NW8575000 |
運輸資料
| UN編號 | UN1544 |
| 類別 | 6.1 |
| 包裝類別 | III |
| HS編碼* | 2939.19-000 |
Application
Papaverine Hydrochloride: An Isoquinoline Alkaloid with Smooth Muscle Relaxation Activity
Papaverine hydrochloride is an isoquinoline alkaloid obtained from opium or prepared synthetically. The most characteristic effect of papaverine is relaxation of the tonus of all smooth muscle. Pharmacological studies suggest that papaverine exerts its effect on by an inhibitory action on phosphodiesterase, resulting in increased intracellular cAMP as well as inhibition of voltage-gated calcium channels. (The product is for research purpose only.)
References
- Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs
- Phosphodiesterase inhibitors
- On the mechanism of papaverine inhibition of the voltage-dependent Ca++ current in isolated smooth muscle cells from the guinea pig trachea
- Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
- Analytical profile of papaverine hydrochloride (a review on the desorption, physical properties, isolation, synthesis, biosynthesis, pharmacokinetics, stability, and determination of it)
考研文獻
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