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CAS RN: 3868-31-3 | 產品號碼: O0661
8-Hydroxyguanosine
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| 產品號碼 | O0661 |
| 純度/分析方法 | >90.0%(T) |
| 分子式 / 分子量 | C__1__0H__1__3N__5O__6 = 299.24 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Air Sensitive,Heat Sensitive |
| CAS RN | 3868-31-3 |
| MDL編號 | MFCD00216136 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 90.0 % |
| Specific rotation | -50.0 to -55.0 deg(C=1, 1mol/L NaOH) |
| NMR | confirm to structure |
性質
GHS
相關法規
| RTECS # | UO8175725 |
運輸資料
| HS編碼* | 2934.99-000 |
Application
8-Hydroxyguanosine (8-Oxo-G): A Biomarker for DNA/RNA Oxidative Stress and Carcinogenesis
8-Hydroxyguanosine (8-oxoguanosine or 8-Oxo-G) is one of the predominant forms of free radical-induced oxidative damage to RNA and can lead to mismatched pairing with adenine, resulting in G to T and C to A substitutions in the genome, and 8-Oxo-G accumulation is associated with many neurodegenerative diseases and cancer.1-3) It is primarily repaired by 8-oxoguanine DNA glycosylase-1 (OGG1).1,4) Therefore, it has been widely used as a biomarker for DNA/RNA oxidative stress and carcinogenesis.5,6)
References
- 1) Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
- 2) Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress
- 3) The emerging role of RNA modifications in the regulation of mRNA stability (a review)
- 4) The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation (a review)
- 5) Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid (a review)
- 6) 8-Hydroxyguanosine as a possible RNA oxidative modification marker in urine from colorectal cancer patients: Evaluation by ultra performance liquid chromatography-tandem mass spectrometry
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