Maximum quantity allowed is 999
请选择数量
CAS RN: 459789-99-2 | 產品號碼: O0641
Obeticholic Acid
×
![]()
×
* 以上價格已含運費關稅等但一些需要海運以及乾冰運輸的產品除外,詳情請與
當地經銷商
洽詢。
* TCI會時常優化儲存條件,儲存溫度請以在線目錄為準，敬請留意。
| 產品號碼 | O0641 |
| 純度/分析方法 | >97.0%(GC)(T) |
| 分子式 / 分子量 | C__2__6H__4__4O__4 = 420.63 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 應避免的情況 | Heat Sensitive |
| CAS RN | 459789-99-2 |
| Reaxys-RN | 9238543 |
| MDL編號 | MFCD16621104 |
產品規格
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 106.0 to 110.0 °C |
| Specific rotation | +3.3 to +5.5 deg(C=1, methanol) |
| NMR | confirm to structure |
性質
| 熔點 | 109 °C |
GHS
相關法規
| RTECS # | FZ2267000 |
運輸資料
| HS編碼* | 2918.19-000 |
Application
Obeticholic Acid: A Potent and Selective Agonist of Farnesoid X Receptor (FXR)
Farnesoid X receptor (FXR), a nuclear receptor, is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic circulation, and a regulator of glucose and lipid metabolism. Obeticholic acid (6-ECDCA, INT-747) is a semi-synthetic mimetic of the primary human bile acid, chenodeoxycholic acid (CDCA) [C0750]. There are reports that obeticholic acid is a potent and selective activator of FXR that reduces hepatic steatosis and fibrosis in animal models of fatty liver disease. (The product is for research purpose only.)
References
- 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action (a review)
- The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (a review)
產品文件 （部分產品的分析圖譜無法提供，敬請諒解。）
SDS
請選擇語言。
請求的SDS不可用。
如需更多幫助，請聯繫我們 。
產品規格
檢驗報告(CoA)及其他文檔
請輸入批號
輸入的批號不正確
示例 CoA
可下載CoA示例。注：該示例可能非最新批次的CoA。
目前沒有該產品的 CoA 示例。
分析圖譜
請輸入批號
輸入的批號不正確
很抱歉，您搜索的分析圖譜無法提供。