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CAS RN: 965-52-6 | 產品號碼: N1181
| 產品號碼 | N1181 |
| 純度/分析方法 | >98.0%(T) |
| 分子式 / 分子量 | C__1__2H__9N__3O__5 = 275.22 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Refrigerated (0-10°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Light Sensitive,Air Sensitive,Heat Sensitive |
| 包裝和容器 | 100MG-Glass Bottle with Plastic Insert （閲覽圖片）, 500MG-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 965-52-6 |
| Reaxys-RN | 4264976 |
| PubChem Substance ID | 468592501 |
| Merck Index(14) | 6535 |
| MDL編號 | MFCD00079482 |
產品規格
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
性質
| 熔點 | 257 °C(dec.) |
GHS
相關法規
| RTECS # | DH2528300 |
運輸資料
| HS編碼* | 2932.19-000 |
Application
Quorum sensing research
Nifuroxazide showed inhibition of quorum sensing-regulated gene expression and related phenotypes in Pseudomonas aeruginosa in a dose-dependent manner. 1)
References
- 1) Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors
Application
Nifuroxazide: An Antibacterial Agent with STAT3 Inhibitory Activity
Nifuroxazide is a broad-spectrum antibacterial agent that has been used for the treatment of infectious diarrhea since 1960’s.1) In 2008, it was discovered that nifuroxazide is a potent inhibitor of the transcription factor STAT3.2) Since then, the potential of nifuroxazide as an anticancer agent has been investigated.3) (The product is for research purpose only.)
References
- 1) In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice
- 2) Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
- 3) Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment (a review)
- 4) Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods
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