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CAS RN: 29745-04-8 | 產品號碼: N0914
| 產品號碼 | N0914 |
| 純度/分析方法 | >98.0%(GC)(T) |
| 分子式 / 分子量 | C__8H__8O__4 = 168.15 |
| 外觀與形狀（20°C） | Solid |
| 儲存條件 | Room Temperature (Recommended in a cool and dark place, <15°C) |
| 儲存在惰性氣體下 | Store under inert gas |
| 應避免的情況 | Moisture Sensitive |
| 包裝和容器 | 1G-Glass Bottle with Plastic Insert （閲覽圖片） |
| CAS RN | 29745-04-8 |
| Reaxys-RN | 84287 |
| PubChem Substance ID | 253659717 |
| MDL編號 | MFCD00213361 |
產品規格
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Methanolysis Method) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
性質
| 熔點 | 115 °C |
GHS
| 圖形表示 |
|
| 信號詞 | Warning |
| 危險性說明 | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| 防範說明 | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
相關法規
| RTECS # | RN8400000 |
運輸資料
| HS編碼* | 2932.19-000 |
Application
抗腫瘍・抗転移作用を有するタンパク質ホスファターゼ阻害剤，ノルカンタリジン
Norcantharidin (NCTD) is the demethylated analog of a natural terpene, cantharidin [C0019]. NCTD has more powerful antitumor activity but less cytotoxicity than cantharidin itself. NCTD is a protein phosphatase inhibitor that induces cell cycle arrest and apoptosis, and also blocks tumor metastasis in cancer cells. (The product is for research purpose only.)
References
- Effects of norcantharidin, a protein phosphatase type-2A inhibitor, on the growth of normal and malignant hemopoietic cells
- Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells
- Norcantharidin-induced apoptosis in oral cancer cells is associated with an increase of proapoptotic to antiapoptotic protein ratio
- Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity
- Small-Molecule Synthetic Compound Norcantharidin Reverses Multi-Drug Resistance by Regulating Sonic Hedgehog Signaling in Human Breast Cancer Cells
- Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery (a review)
考研文獻
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